Brand name: Celexa.
Main substance: citalopram.
Dosage form: oval tablets with a dividing notch and embossing «FP» on one side and the strength of dosage on the other side; the color indicates the content of the active substance:
- beige — 10 mg;
- orange — 20 mg;
- white — 40 mg.
Pharmacology of Celexa
The action of this drug is based on the selective inhibition of reuptake of serotonin by neurons of the central nervous system. There is almost no effect on adrenergic, m-cholinergic and histamine receptors.
Peak concentration of the main substance in the blood plasma is reached in about two to four hours after administration. Approximately 80% is bound to plasma proteins. Bioavailability is about 80%.
The half-life is approximately one and a half days. Celexa is excreted through the kidneys and intestines.
The dosage of Celexa
The drug is taken orally once daily in the following recommended therapeutic doses:
- children up to the age of 11 years: initial dose is 10 mg followed by an increase of 5 mg every two weeks up to a maximum dose of 40 mg;
- children from twelve to eighteen years of age: initial dose is 10-20 mg with a gradual increase of 10 mg every two weeks up to a maximum dose of 40 mg;
- adult patients: initial dose is 10-20 mg with a possible further increase up to 60 mg;
- patients over the age of 65 years: initial dose is 20 mg followed by an increase up to maximum 40 mg.
Interactions with other drugs
Development of hypertensive crisis is possible with the combined therapy of Celexa and monoamine oxidase inhibitors.
There is a likelihood of reduction in the concentration of active substance in plasma due to its rapid excretion if administered along with carbamazepine and induction of liver enzymes by the latter.
The concentration of citalopram in plasma can increase when used in conjunction with cimetidine.
The effect of the use of drugs that interact with serotonergic neurons may be elevated by the simultaneous use of Celexa.
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